Bayer Oncology Medical Affairs Department is interested in receiving and reviewing grant applications to support appropriate programs which cover the following area of interest:
Therapeutic Areas/Disease States:
Central Nervous System (CNS) Cancers
Intended Audience: Oncologists, Surgeons, Pathologists, Community HCPs, Patients/Caregivers
Areas of interest based on referenced literature:
- Management and treatment of CNS cancers
- Role of NTRK gene fusions and impact of TRK-fusion testing in treatment algorithms for local, regional and/or CNS cancers
- Education on biomarker driven testing strategies/appropriate testing modalities
- Multi-disciplinary approach to precision medicine
- Understanding of efficacy and safety profiles of approved TRK inhibitors in local, regional and/or CNS cancers
- Role of Tyrosine Kinase Inhibitors (TKIs) in metastatic CNS cancer treatment algorithms
- Prevention and management of adverse events due to TKIs
Proposal Requirements:
All submissions for CE/CME support must be consistent with the ACCME guidelines and contain supporting documents that should include:
- Needs assessment
- Educational design and rationale for selection (where applicable)
- Learning objectives
- Proposed faculty
- Participant recruitment plan (where applicable)
- Outcomes strategy/plan (required on a quarterly basis)
- Detailed budget
Provider Justification:
- Copy of most recent accreditation letter and status
- Sample of other program(s) in similar therapeutic area
Process
Applications/proposals which are submitted and determined to be complete are reviewed monthly. Allow a minimum of 45 days from submission for response.
Acceptance of a Bayer educational grant indicates that you will:
- Reconcile grant funding within 60 days of completion of the educational program
- Permit a BHC Medical Affairs representative to audit live programs
- Share activity data and outcomes metrics within 30 days of their availability
References
Management and treatment of CNS cancers
- 1. NIH – Surveillance, Epidemiology and End Results Program. Cancer Stat Facts: Brain and Other Nervous System Cancer. (link)
- 2. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Central Nervous System Cancers. Version 2.2019 – September 16, 2019 (link)
Diagnosis, treatment and management of TRK fusion cancer
- Nagasubramanian R, Wei J, Gordon P, Rastatter JC et al. Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101. Pediatr Blood Cancer. 2016 Aug;63(8):1468-70. (link)
- Hong DS, Bauer TM, Lee JJ et al. Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study. Ann Oncol. 2019 Feb 1;30(2):325-331. (link)
- Khotskaya YB, Holla VR, Farago AF, et al. Targeting TRK family protein in cancer. Pharmacol Ther 2017 (173), 58-66. (link)
- Drilon A, Laetsch TW, Kummar S et al. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. N Engl J Med 2018; 378: 731-9. (link)
- Cocco, E et al. NTRK fusion-positive cancers and TRK inhibitor therapy. Nat Rev Clin Oncol. 2018 Dec;15(12):731-747. (link)
- Hyman, DM et al. Durability of response with larotrectinib in adult and paediatric patients with TRK fusion cancer. Annals of Oncology 30 (5), October 2019 (link)
- Kummar, S et al. Patient-reported outcomes from two global multicenter clinical trials of children and adults with tropomyosin receptor kinase (TRK) fusion cancers receiving larotrectinib. Journal of Clinical Oncology 37, 2019 (suppl; abstr 6602) (link)
- Ricciuti, B et al. Antitumor activity of larotrectinib in tumors harboring NTRK gene fusions: a short review on the current evidence. Onco Targets Ther. 2019 Apr 30;12:3171-3179 (link)
- Solomon, JP et al. NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls. Mod Pathol. 2019 Aug 2. (Epub ahead of print) (link)
- Wong, D et al. Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer. Pathol Oncol Res. 2019 Jun 29. (Epub ahead of print) (link)
- Drilon, AE et al. Activity of larotrectinib in TRK fusion cancer patients with brain metastases or primary central nervous system tumors. Journal of Clinical Oncology 37, 2019 (suppl; abstr 2006) (link)
- Ziegler DS, Wong M, Mayoh C et al. Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma. Br J Cancer. 2018 Sep;119(6):693-696. (link)
- Walter, AW et al. Larotrectinib imaging response in low-grade glioma. Pediatr Blood Cancer. 2020 Jan;67(1):e28002(link)
- Perreault, S. et al. Efficacy and safety of larotrectinib in adult and pediatric patients with tropomyosin receptor kinase (TRK) fusion-positive primary central nervous system (CNS) tumors. ASCO 2021 abstract.(link)
- Doz F, van Tilburg CM, Geoerger B, Højgaard M, Øra I, et al. Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors. Neuro Oncol. 2022 Jun 1;24(6):997-100. (link)
- Perreault, S. et al. Long-term control and safety of larotrectinib in a cohort of adult and pediatric patients with tropomyosin receptor kinase (TRK) fusion primary central nervous system (CNS) tumors. ASCO 2022 abstract.(link)
Role of Tyrosine Kinase Inhibitors (TKIs) in CNS cancers
- Jiang J, et al. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. Autophagy. 2019 Mar 25:1-17. (link)
- Lombardi, G et al. Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial. Lancet Oncol. 2019 Jan;20(1):110-119. (link)